Discovery Pharma Consulting LLC

Dr. Lars J. S. Knutsen is a results-driven Pharma R&D Leader, Drug Discovery Consultant and Senior Medicinal Chemist, with demonstrable expertise in design and selection of Drug Candidates.  He has excellent analytical skills and deep strategic knowledge of the Pharma and Biotech industry, being closely involved in invention of 8 New Chemical Entities (NCEs), of which 6 progressed to clinical trials, including Vipadenant (Parkinson’s Disease), Irdabisant (Cognition) and Requisom (Obstructive Sleep Apnea); the anticonvulsant Gabitril™ is FDA approved and marketed worldwide.

He has a broad background in Drug Discovery and Development, especially medicinal chemistry focused on treatments for neuromuscular disease, epilepsy, sleep disorders, cognition, neurodegeneration and pain.  He has motivated teams of scientists to achieve goals in 6 companies over a 30+ year Pharma/Biotech career in 3 countries and 2 continents.  He is a peer recognized high-level heterocyclic, nucleoside/ carbohydrate chemist.

Lars was appointed an Adjunct Professor at Drexel University School of Medicine in 2009; regular major conference speaker with 45 peer-reviewed publications, 34 published PCT patents; 24 of these are issued in US.  He Chaired Patent Committees at Ionix Pharma and Vernalis PLC; strong knowledge of patenting process in US/EU with its manifold issues, and has been involved in 18 Expert Witness cases since 2011. He served as a Member of NIMH/NCDDDG Grant Review Panel, 2010-11 and participated in a NIH-NIDDK Intramural Staff Review in 2016. As an articulate and creative scientific leader with excellent interpersonal skills, methodical and focused he has an excellent knowledge of drug design. Biology and PK/ADME knowledge from leading successful clinical drug discovery efforts. Lars is a Fellow of the Royal Society of Chemistry, and ACS/SfN member; US Citizenship gained in 2015.

Lars was raised in England of Norwegian parents, and is a US Permanent Resident.  He can therefore consult in North America and Europe.

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